Pathophysiology of Adipose Tissue Metabolism and Atherosclerosis in Familial Combined Hyperlipidemia
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چکیده
منابع مشابه
Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile.
Familial combined hyperlipidemia (FCH) is characterized by increased levels of total cholesterol, triglycerides, and/or apolipoprotein B. Other features of FCH are obesity and insulin resistance. Adiponectin is a secretory product of the adipose tissue. Low levels of adiponectin are associated with insulin resistance and accelerated atherosclerosis. The aim of this study was to determine whethe...
متن کاملPathway analysis detect potential mechanism for familial combined hyperlipidemia.
BACKGROUND Familial combined hyperlipidemia (FCHL) is the most commonly inherited hyperlipidemia in men. It constitutes a substantial risk factor for atherosclerosis patients. AIM To delineating the potential mechanism of FCHL by bioinformatics tools. MATERIALS AND METHODS In this study, Protein-Protein Interaction (PPI) network was constructed to identify the potential functional proteins ...
متن کاملThe adipocyte, fatty acid trapping, and atherogenesis.
Much effort has been spent to identify the factors that contribute to coronary artery disease. Not surprisingly, adipose tissue has gained little attention to date in this search because no immediate and critical links between adipocyte metabolism and atherogenesis may be evident to most people. But coronary artery disease is a public health problem only in societies with high fatty acid intake...
متن کاملDifferential gene expression of blood-derived cell lines in familial combined hyperlipidemia.
OBJECTIVES The genetic background of familial combined hyperlipidemia (FCHL) is currently unclear. We propose transcriptional profiling as a complementary tool for its understanding. Two hypotheses were tested: the existence of a disease-specific modification of gene expression in FCHL and the detectability of such a transcriptional profile in blood derived cell lines. METHODS AND RESULTS We ...
متن کاملComparison of Epicardial Adipose Tissue Fatty Acid Profile in Cardiovascular Disease Patients Diabetic and Non-Diabetic
ABSTRACT Background and Objective: The relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. The aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease. &nb...
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